Spice Extract May Induce Death of Mesothelioma Cells Curcumin, a derivative of the spice turmeric, has come into the medical spotlight as a potential agent in treating mesothelioma. Recent in vitro and in vivo studies have investigated the turmeric-based compound's ability to induce apoptosis, or programmed cell death. Curcumin has also been studied in conjunction with chemotherapy drugs to measure its affect on the impact of chemotherapeutic treatment. Malignant mesothelioma, which develops in the linings of certain internal organs, frequently alters cell cycles and apoptosis pathways. This makes the cells very difficult to kill via chemotherapy or radiation therapy. As a result, strategies to make the cells more responsive to treatment are a major focus of mesothelioma research. After observing biological and molecular responses by malignant pleural mesothelioma cells, researchers found that mesothelioma cells from laboratory mice and humans can be suppressed by exposure to the curcumin. Oral administration of curcumin was able to suppress cell growth in levels that were directly related to the dose of the compound. Additionally, pretreatment with curcumin made mesothelioma cells more.... Read More» |
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